Big chance for Pacheco.
This from the offal:
Hodgson told us: "Danny Wilson will play on Wednesday night. Soto Kyrgiakos and Daniel Agger will be the two centre-backs and Danny will play left-back. He came here as a centre-back but is capable of playing at full-back in the same way we think Martin Kelly is capable of playing in this position.
"He's a player with great potential, very comfortable on the ball.
"Brad Jones is an international goalkeeper for Australia and he's played many games for Middlesbrough. I have no doubts about him and his competence.
"Pepe Reina is a fantastic character who wants to play every game, whether it's a seven-a-side in training or any game Liverpool Football Club plays, but it's important that Brad gets his chance.
"Goalkeepers have got to be a very special breed. You need a character who is good enough for the Premier League but who also understands that there's another goalkeeper at the club who's probably better than him.
"You look for an exceptional person and then all you can do is try to keep them on board as much as you can. That is done by treating them with the proper respect in training, and that's very important, and by giving them a chance to play when the opportunity presents itself."
Further up the field, Hodgson is likely to put his trust in players like Dani Pacheco, Ryan Babel and David Ngog.
The boss said: "I'm quite interested in Dani as well. He's a player who came back a little later after taking part in the U19 European Championships. He's impressed in training and looks like a very interesting prospect. His first-team chances have been limited because he wasn't in Switzerland in pre-season, where he would have played for sure.
"I'm really looking forward to seeing him play on Wednesday night, and it's another great chance for Ryan Babel and David Ngog to stake their claim for a place in the team."
Despite the changes, Hodgson is adamant the League Cup is a competition Liverpool are taking seriously.
"It's a strange game for us in a sense. It's one where we definitely need to rotate the squad having played so many games, and with us having to play so many more before the international break," he explained.
"But on the other hand it's a competition I take very seriously and I want to have a good run in the competition. We are bothered.
"There's a responsibility on those who replace the big-name players like Steven Gerrard, Fernando Torres, Pepe Reina and Jamie Carragher to name but four. And to be fair they've shown themselves capable of taking on that burden in a couple of European matches already.
"As we saw in the last game against Steaua Bucharest, Jay Spearing was arguably one of the best players on the field. If you never give him a chance, how do you know that?"