Locker is at the top of the lists now, but if Andrew Luck comes out next year I think he is a far better player. Ryan Mallet will also probably come out early as the QBs will want to avoid the rookie payscale in any new CBA the following season. Pryor is good, but everyone went batshit over his Rose Bowl. If he plays like that regularly, then yeah. But we'll see. There's a lot of pressure on him right now. Christian Ponder at FSU is a very good player. There will be a lot of attention on Case Keenum at Houston (their schedule could see them go unbeaten) and Andy Dalton at TCU, who is a really improved player.
I really like Kellen Moore at Boise. If they go unbeaten again this year (which they will if they beat Virginia Tech in the opener) then they'll definitely be in a BCS game and will probably be in the national unless Texas and Ohio go unbeaten too. If the breaks go for them and they play for the title, then he will be a serious Heisman candidate. He's a tad small though, which might scare off pro scouts (under 200lbs). If he bulks up though I think he's a genuine prospect.
And there are a ton of players who will make solid back up signal callers. McElroy at Bama, Nathan Enderle, Ricky Stanzi, Scott Tolzien if he comes out. Then you have Tyrod Taylor and Colin Kaepernick, who both play in gadget offences. Taylor has decent hands and might be a pick up as a WR/wildcat QB. Kaepernick is loads of fun to watch at Nevada (the most entertaining college team last year - yards all over the fucking place) but he would get smoked in the pros. He'll go into the draft but I don't see anyone taking him early. If at all. Might go as an unsigned free after. As might Mitch Mustain. He's a USC QB but will get no field time because of Barkley (unless the kid gets nuked), but any USC QB is pro-trained so will interest someone either late on or as a free.