For me, the question is about whether to field Sturridge in tandem with the in-form Origi. They may not have a strong partnership going yet, but there's a lot to like about what each offers and the potential for them to click and take off. I think under Klopp, Sturridge has had to play a lot more of the role that Suarez did for him under Rodgers - dropping deep, linking plays, pressing opponents, etc. Fair enough if that's how Klopp likes his strikers, but Sturridge is such a great scorer and creator in and around the box (and a much better player in those areas than in deep areas) that taking him further from the box just saps his energy and takes him away from where he's most lethal. Origi's pace, strength, stamina, directness and work rate, on the other hand, will be more useful for the team in these deeper zones. I can see how this partnership could work with Origi turning possession wins and retention into feeds for Sturridge (or for Lallana / Coutinho to then supply Sturridge) in the latter's favoured danger zones.
I'm tempted to want Klopp to start with the following front six, with Origi swapping positions with Coutinho and Lallana during the course of the game depending on matchups that occur. Firmino can then come in with fresh legs for the second half and still keep the pressure up.
----------- Can -------- Milner ---------
Lallana -------- Origi ------- Coutinho
--------------- Sturridge ----------------