Sunday's tie is particularly exciting for several Liverpool fans within the Town dressing room, led by manager Sam Ricketts.
Ricketts, son of former world champion show jumper Derek Ricketts and nephew of champion jump jockey John Francome, admitted: "I was a Liverpool fan but I only really supported them as a mate of mine did. I was more interested in horses then."
But, for Merseyside-born Shaun Whalley, who has become the club's longest-serving player since joining from Luton in 2015, this is a dream.
"All my family are Liverpool fans," he said. "My mates are season-ticket holders and I was at the Champions League final in Istanbul in 2005.
"This is brilliant for me, especially having got to the age of 32 and thinking you're never going to play against them."
It also caps a remarkable turn of events for former Liverpool junior Sam Hart, who is eligible to play against them after signing on loan from Blackburn Rovers just a week ago.
"The first thing the gaffer [Tony Mowbray] mentioned when he told me Shrewsbury wanted me was that I'd be able 'to catch up with a few old mates'," he grinned.
He played just once for Liverpool manager Jurgen Klopp, but he has not forgotten it, getting flown out by private jet for a pre-season friendly in Germany.
"I remember it like it was yesterday," he said. "And then getting the call from Jurgen saying I was coming on.
"Having grown up there, to put a shirt on and play against them would be special