In theory we should be okay with Carra, Agger and Skrtel. All three are good players who will expect to play lots of games. And so they should, as the effectiveness of the defensive unit relies upon all members having an understanding with each other.
If all three stay fit then that is a problem in itself, especially as we now won't have the option of moving Carra to right back every so often. Buying another defender will therefore only increase this problem.
However, as the last few seasons have shown, defenders staying fit and available is an issue. We shouldn't really have needed Sami so much in the last few years (even though for my money he was possibly the better option than some anyway, even if was regarded as backup).
We have enough defenders in the reserves, so give one of them a go. If all goes to plan whoever it is won't need to play that much but if they do and if they are good then great, we might save ourselves some money in the future. If they are not so good then we can always try to get someone in in January.
What we will learn though is whether or not Carra, Skrtel and Agger are reliable enough. If we need to go outside of them then the answer will clearly be no and we will need to make changes next year.